{"id":37,"date":"2024-03-04T10:07:05","date_gmt":"2024-03-04T10:07:05","guid":{"rendered":"https:\/\/www.verginadislab.org\/?p=37"},"modified":"2025-02-05T12:05:13","modified_gmt":"2025-02-05T12:05:13","slug":"selected-publications","status":"publish","type":"post","link":"https:\/\/www.verginadislab.org\/?p=37","title":{"rendered":"Selected publications"},"content":{"rendered":"<ul>\n<li style=\"text-align: justify;\"><span style=\"font-size: 14pt;\"><strong>Verginadis II<\/strong>, Velalopoulou A, Kim MM, Kim K, Paraskevaidis I, Bell B, Oliaei Motlagh SA, Karaj A, Banerjee E, Finesso G, Assenmacher CA, Radaelli E, Lu J, Lin Y, Putt ME, Diffenderfer ES, Guha C, Qin L, Metz JM, Maity A, Cengel KA, Koumenis C, Busch TM. FLASH proton reirradiation, with or without hypofractionation, reduces chronic toxicity in the normal murine intestine, skin, and bone. Radiother Oncol. 2025. PMID: 39880309.<\/span><\/li>\n<\/ul>\n<ul>\n<li style=\"text-align: justify;\"><span style=\"font-size: 14pt;\"><strong>Verginadis II<\/strong>, Citrin DE, Ky B, Feigenberg SJ, Georgakilas AG, Hill-Kayser CE, Koumenis C, Maity A, Bradley JD, Lin A. Radiotherapy toxicities: mechanisms, management, and future directions. Lancet. 2025. PMID: 39827884.<\/span><\/li>\n<\/ul>\n<ul>\n<li style=\"text-align: justify;\"><span style=\"font-size: 14pt;\"><span style=\"font-size: 14pt;\">Kyle Kim#, Michele M. Kim#, Giorgos Skoufos, Eric S. Diffenderfer, Seyyedeh Azar Oliaei Motlagh, Michail Kokkorakis, Ilektra Koliaki, George Morcos, Khayrullo Shoniyozov, Joanna Griffin, Artemis G. Hatzigeorgiou, James M. Metz, Alexander Lin, Steven J. Feigenberg, Keith A. Cengel, Bonnie Ky, Constantinos Koumenis, <strong>Ioannis I. Verginadis<\/strong>. FLASH proton radiotherapy mitigates inflammatory and fibrotic pathways and preserves cardiac function in a preclinical mouse model of radiation-induced heart disease. <span style=\"text-decoration: underline;\">IJROBP<\/span> 2024 (<em>#Authors contributed equally to this study<\/em>). PMID: 38364948.<\/span><\/span><\/li>\n<\/ul>\n<ul>\n<li style=\"text-align: justify;\"><span style=\"font-size: 14pt;\"><span style=\"font-size: 14pt;\"><strong>Ioannis I. Verginadis<\/strong>, Harris Avgousti, James Monslow, Giorgos Skoufos, Frank Chinga, Kyle Kim, Nektaria Maria Leli, Ilias V. Karagounis, Brett I. Bell, Anastasia Velalopoulou, Carlo Salas Salinas, Victoria S. Wu, Yang Li, Jiangbin Ye, David A. Scott, Andrei L. Osterman, Arjun Sengupta, Aalim Weljie, Menggui Huang, Duo Zhang, Yi Fan, Enrico Radaelli, John W. Tobias, Jonathan Schug, Florian Rambow, Panagiotis Karras, Jean-Christophe Marine, Xiaowei Xu, Artemis G. Hatzigeorgiou, Sandra Ryeom, Alan J. Diehl, Serge Y. Fuchs, Ellen Pur\u00e9, and Constantinos Koumenis. An Integrated Stress Response Pathway activates Perivascular Cancer-Associated Fibroblasts to Drive Angiogenesis and Tumor Progression. <span style=\"text-decoration: underline;\">Nature Cell Biology<\/span> 2022; <a href=\"https:\/\/doi.org\/10.1038\/s41556-022-00918-8\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1038\/s41556-022-00918-8<\/a>.<\/span><\/span><\/li>\n<\/ul>\n<ul>\n<li style=\"text-align: justify;\"><span style=\"font-size: 14pt;\"><span style=\"font-size: 14pt;\">Alexandra D. Dreyfuss, Anastasia Velalopoulou, Harris Avgousti, Brett I. Bell and <strong>Ioannis I. Verginadis<\/strong>. Preclinical models of radiation-induced cardiac toxicity: Potential mechanisms and biomarkers. <span style=\"text-decoration: underline;\">Frontiers in Oncology<\/span> 2022; 12:920867, PMID: 36313656.<\/span><\/span><\/li>\n<\/ul>\n<ul>\n<li style=\"text-align: justify;\"><span style=\"font-size: 14pt;\"><span style=\"font-size: 14pt;\">Michele M. Kim*, <strong>Ioannis I. Verginadis*<\/strong>, Denisa Goia, Allison Haertter, Khayrullo Shoniyozov, Wei Zou, Amit Maity, Theresa M. Busch, James Metz, Keith Cengel, Lei Dong, Costas Koumenis and Eric S. Diffenderfer. Comparison of FLASH proton entrance and the spread-out Bragg peak dose regions in the sparing of mouse intestinal crypts and in a pancreatic tumor model. <span style=\"text-decoration: underline;\">Cancers<\/span> 2021; 23;13(16):4244. (<em>*authors contributed equally to this study<\/em>). PMID: 34439398.<\/span><\/span><\/li>\n<\/ul>\n<ul>\n<li style=\"text-align: justify;\"><span style=\"font-size: 14pt;\"><span style=\"font-size: 14pt;\">Alexandra D. Dreyfuss, Denisa Goia, Khayrullo Shoniyozov, Swapnil V. Shewale, Anastasia Velalopoulou, Susan Mazzoni, Harris Avgousti, Scott D. Metzler, Paco E. Bravo, Steven J Feigenberg, Bonnie Ky, <strong>Ioannis Verginadis*<\/strong>, Constantinos Koumenis*. A novel mouse model of radiation-induced cardiac injury reveals biological and radiological biomarkers of cardiac dysfunction with potential clinical relevance. <span style=\"text-decoration: underline;\">Clinical Cancer Research<\/span> 2021;27(8):2266-2276. (<em>*co-senior and co-corresponding authors<\/em>). PMID: 33542079.<\/span><\/span><\/li>\n<\/ul>\n<ul>\n<li style=\"text-align: justify;\"><span style=\"font-size: 14pt;\"><span style=\"font-size: 14pt;\">Eric S. Diffenderfer\u00a7, <strong>Ioannis I. Verginadis\u00a7<\/strong>, Michele M. Kim\u00a7, Khayrullo Shoniyozov, Anastasia Velalopoulou, Denisa Goia, Mary Putt, Sarah Hagan, Stephen Avery, Kevin Teo, Wei Zou, Alexander Lin, Samuel Swisher-McClure, Cameron Koch, Ann R Kennedy, Andy Minn, Amit Maity, Theresa M. Busch, Lei Dong, Costas Koumenis, James Metz, Keith A Cengel. Design, implementation and in vivo validation of a novel proton FLASH radiotherapy system. <span style=\"text-decoration: underline;\">Int J Radiat Oncol Biol Phys<\/span> 2020;106(2):440-448. (<em>\u00a7Authors contributed equally to this study<\/em>). PMID: 31928642.<\/span><\/span><\/li>\n<\/ul>\n<ul>\n<li style=\"text-align: justify;\"><span style=\"font-size: 14pt;\"><span style=\"font-size: 14pt;\">Feven Tameire, <strong>Ioannis I. Verginadis<\/strong>, Nektaria Maria Leli, Christine Polte, Crystal S. Conn, Rani Ojha, Carlo Salas Salinas, Frank Chinga, Alexandra M. Monroy, Weixuan Fu, Paul Wang, Andrew Kossenkov, Jiangbin Ye, Ravi K. Amaravadi, Zoya Ignatova, Serge Y. Fuchs, J. Alan Diehl, Davide Ruggero and Constantinos Koumenis. ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression. <span style=\"text-decoration: underline;\">Nature Cell Biology<\/span> 2019;21(7):889-899. PMID: 31263264.<\/span><\/span><\/li>\n<\/ul>\n<ul>\n<li style=\"text-align: justify;\"><span style=\"font-size: 14pt;\"><strong>Ioannis I. Verginadis<\/strong>, Rahul Kanade, Brett Bell, Sravya Koduri, Edgar Ben-Josef and Constantinos Koumenis. A novel mouse model to study image-guided, radiation-induced intestinal injury and preclinical screening of radioprotectors. <span style=\"text-decoration: underline;\">Cancer Res<\/span> 2017;77(4):908-917. PMID: 28011621.<\/span><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Verginadis II, Velalopoulou A, Kim MM, Kim K, Paraskevaidis I, Bell B, Oliaei Motlagh SA, Karaj A, Banerjee E, Finesso G, Assenmacher CA, Radaelli E, Lu J, Lin Y, Putt ME, Diffenderfer ES, Guha C, Qin L, Metz JM, Maity A, Cengel KA, Koumenis C, Busch TM. FLASH proton reirradiation, with or without hypofractionation, reduces <a class=\"read-more\" href=\"https:\/\/www.verginadislab.org\/?p=37\"><\/p>\n<p>Read More<\/p>\n<p><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-37","post","type-post","status-publish","format-standard","hentry","category-publications"],"_links":{"self":[{"href":"https:\/\/www.verginadislab.org\/index.php?rest_route=\/wp\/v2\/posts\/37","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.verginadislab.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.verginadislab.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.verginadislab.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.verginadislab.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=37"}],"version-history":[{"count":9,"href":"https:\/\/www.verginadislab.org\/index.php?rest_route=\/wp\/v2\/posts\/37\/revisions"}],"predecessor-version":[{"id":211,"href":"https:\/\/www.verginadislab.org\/index.php?rest_route=\/wp\/v2\/posts\/37\/revisions\/211"}],"wp:attachment":[{"href":"https:\/\/www.verginadislab.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=37"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.verginadislab.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=37"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.verginadislab.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=37"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}