Selected publications

  • Kyle Kim#, Michele M. Kim#, Giorgos Skoufos, Eric S. Diffenderfer, Seyyedeh Azar Oliaei Motlagh, Michail Kokkorakis, Ilektra Koliaki, George Morcos, Khayrullo Shoniyozov, Joanna Griffin, Artemis G. Hatzigeorgiou, James M. Metz, Alexander Lin, Steven J. Feigenberg, Keith A. Cengel, Bonnie Ky, Constantinos Koumenis, Ioannis I. Verginadis. FLASH proton radiotherapy mitigates inflammatory and fibrotic pathways and preserves cardiac function in a preclinical mouse model of radiation-induced heart disease. IJROBP 2024 (#Authors contributed equally to this study). PMID: 38364948.
  • Ioannis I. Verginadis, Harris Avgousti, James Monslow, Giorgos Skoufos, Frank Chinga, Kyle Kim, Nektaria Maria Leli, Ilias V. Karagounis, Brett I. Bell, Anastasia Velalopoulou, Carlo Salas Salinas, Victoria S. Wu, Yang Li, Jiangbin Ye, David A. Scott, Andrei L. Osterman, Arjun Sengupta, Aalim Weljie, Menggui Huang, Duo Zhang, Yi Fan, Enrico Radaelli, John W. Tobias, Jonathan Schug, Florian Rambow, Panagiotis Karras, Jean-Christophe Marine, Xiaowei Xu, Artemis G. Hatzigeorgiou, Sandra Ryeom, Alan J. Diehl, Serge Y. Fuchs, Ellen Puré, and Constantinos Koumenis. An Integrated Stress Response Pathway activates Perivascular Cancer-Associated Fibroblasts to Drive Angiogenesis and Tumor Progression. Nature Cell Biology 2022; https://doi.org/10.1038/s41556-022-00918-8.
  • Alexandra D. Dreyfuss, Anastasia Velalopoulou, Harris Avgousti, Brett I. Bell and Ioannis I. Verginadis. Preclinical models of radiation-induced cardiac toxicity: Potential mechanisms and biomarkers. Frontiers in Oncology 2022; 12:920867, PMID: 36313656.
  • Michele M. Kim*, Ioannis I. Verginadis*, Denisa Goia, Allison Haertter, Khayrullo Shoniyozov, Wei Zou, Amit Maity, Theresa M. Busch, James Metz, Keith Cengel, Lei Dong, Costas Koumenis and Eric S. Diffenderfer. Comparison of FLASH proton entrance and the spread-out Bragg peak dose regions in the sparing of mouse intestinal crypts and in a pancreatic tumor model. Cancers 2021; 23;13(16):4244. (*authors contributed equally to this study). PMID: 34439398.
  • Alexandra D. Dreyfuss, Denisa Goia, Khayrullo Shoniyozov, Swapnil V. Shewale, Anastasia Velalopoulou, Susan Mazzoni, Harris Avgousti, Scott D. Metzler, Paco E. Bravo, Steven J Feigenberg, Bonnie Ky, Ioannis Verginadis*, Constantinos Koumenis*. A novel mouse model of radiation-induced cardiac injury reveals biological and radiological biomarkers of cardiac dysfunction with potential clinical relevance. Clinical Cancer Research 2021;27(8):2266-2276. (*co-senior and co-corresponding authors). PMID: 33542079.
  • Eric S. Diffenderfer§, Ioannis I. Verginadis§, Michele M. Kim§, Khayrullo Shoniyozov, Anastasia Velalopoulou, Denisa Goia, Mary Putt, Sarah Hagan, Stephen Avery, Kevin Teo, Wei Zou, Alexander Lin, Samuel Swisher-McClure, Cameron Koch, Ann R Kennedy, Andy Minn, Amit Maity, Theresa M. Busch, Lei Dong, Costas Koumenis, James Metz, Keith A Cengel. Design, implementation and in vivo validation of a novel proton FLASH radiotherapy system. Int J Radiat Oncol Biol Phys 2020;106(2):440-448. (§Authors contributed equally to this study). PMID: 31928642.
  • Feven Tameire, Ioannis I. Verginadis, Nektaria Maria Leli, Christine Polte, Crystal S. Conn, Rani Ojha, Carlo Salas Salinas, Frank Chinga, Alexandra M. Monroy, Weixuan Fu, Paul Wang, Andrew Kossenkov, Jiangbin Ye, Ravi K. Amaravadi, Zoya Ignatova, Serge Y. Fuchs, J. Alan Diehl, Davide Ruggero and Constantinos Koumenis. ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression. Nature Cell Biology 2019;21(7):889-899. PMID: 31263264.
  • Ojha R, Leli NM, Onorati A, Piao S, Verginadis II, Tameire F, Rebecca VW, Chude CI, Murugan S, Fennelly C, Noguera-Ortega E, Liu S, Xu X, Krepler C, Xiao M, Xu W, Wei Z, Frederick DT, Boland G, Mitchell TC, Karakousis GC, Schuchter LM, Flaherty KT, Zhang G, Herlyn M, Koumenis C, Amaravadi RK. ER Translocation of the MAPK Pathway Drives Therapy Resistance in BRAF-Mutant Melanoma. Cancer Discovery 2019;9(3):396-415. PMID: 30563872.
  • Ioannis I. Verginadis, Rahul Kanade, Brett Bell, Sravya Koduri, Edgar Ben-Josef and Constantinos Koumenis. A novel mouse model to study image-guided, radiation-induced intestinal injury and preclinical screening of radioprotectors. Cancer Res 2017;77(4):908-917. PMID: 28011621.